Handler "WebServiceHandlerFactory-Integrated" has a bad module "ManagedPipelineHandler" in its module list.

 原因：在安装Framework v4.0之后，再启用IIS，导致Framework没有完全安装

解决：开始->所有程序->附件->鼠标右键点击“命令提示符”->以管理员身份运行->%windir%\Microsoft.NET\Framework\v4.0.30319\aspnet_regiis.exe -i

OK！